Sickle Cell Anaemia is caused by a base mutation in the DNA sequence. The effect of this mutation is a change in the structure of the protein, which affects the ability of haemoglobin to transport oxygen around the body. This is a great explanation that links protein synthesis, gene mutation and protein function together. https://www.dnalc.org/resources/3d/17-sickle-cell.html
https://www.dnalc.org/resources/3d/17-sickle-cell.html